TLR-activated conventional DCs promote γ-secretase-mediated conditioning of plasmacytoid DCs
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چکیده
منابع مشابه
The Balance between Conventional DCs and Plasmacytoid DCs Is Pivotal for Immunological Tolerance during Pregnancy in the Mouse
Dendritic cells (DCs), which can shape their functions depending on the microenvironment, are crucial for the delicate balance of immunity and tolerance during pregnancy. However, the mechanism underlying the microenvironment-educated plasticity of DC differentiation during pregnancy remains largely unclear. Here, we found that the differentiation of conventional DCs (cDCs) and plasmacytoid DCs...
متن کاملDifferential requirement for DOCK2 in migration of plasmacytoid DCs versus myeloid DCs
Correspondence: Yoshinori Fukui, Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan e-mail: [email protected] phone: 81(Japan)-92-642-6828 fax: 81(Japan)-92-632-0150 Blood First Edition Paper, prepublished online January 15, 2008; DOI 10.1182/blood-2007-09-...
متن کاملPlasmacytoid DCs, exposed to TSLP in synergy with TLR ligands, acquire significant potential towards Th2 polarization
BACKGROUND Thymic stromal lymphopoietin (TSLP) has been reported to activate myeloid dendritic cells (mDCs) to induce Th2 T lymphocyte responses. Its effect on plasmacytoid dendritic cells (pDCs) with TLR ligands has not yet been studied. We investigated the effects of TSLP and TLR ligands on mDCs and pDCs subsets. MATERIAL AND METHODS Myeloid dendritic cells (mDC) and plasmacytoid dendritic ...
متن کاملPlasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs
Antiviral cell-mediated immunity is initiated by the dendritic cell (DC) network in lymph nodes (LNs). Plasmacytoid DCs (pDCs) are known to migrate to inflamed LNs and produce interferon (IFN)-alpha, but their other roles in antiviral T cell immunity are unclear. We report that LN-recruited pDCs are activated to create local immune fields that generate antiviral cytotoxic T lymphocytes (CTLs) i...
متن کاملThe transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2
Plasmacytoid dendritic cells (DCs [pDCs]) develop from pre-pDCs, whereas two lineages of conventional DCs (cDCs; cDC1s and cDC2s) develop from lineage-committed pre-cDCs. Several transcription factors (TFs) have been implicated in regulating the development of pDCs (E2-2 and Id2) and cDC1s (Irf8, Id2, and Batf3); however, those required for the early commitment of pre-cDCs toward the cDC2 linea...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2012
ISSN: 0741-5400
DOI: 10.1189/jlb.0911452